Marbofloxacin EP Impurity E HCl CAS 2249835-04-7 (free base)
| CAS No. | 2249835-04-7 (free base) |
| Molecular Formula | C18H23FN4O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 414.86 g/mol gives Marbofloxacin EP Impurity E HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Marbofloxacin EP Impurity E HCl (CAS 2249835-04-7 (free base)), a pharmacopoeial impurity reference standard (molecular formula C18H23FN4O4HCl, MW 414.86 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Marbofloxacin EP Impurity E HCl (C18H23FN4O4HCl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H23FN4O4 HCl |
| Molecular Weight | 414.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Marbofloxacin Standards
- Marbofloxacin EP Impurity C (CAS 100276-37-7)
- Marbofloxacin Impurity 9 (CAS 100276-67-3)
- Marbofloxacin (CAS 115550-35-1)
- Marbofloxacin Hydrochloride (CAS 115551-26-3)
- Marbofloxacin EP Impurity A (CAS 115551-40-1)
- Marbofloxacin EP Impurity B (CAS 115551-41-2)
- Marbofloxacin EP Impurity D (CAS 117380-92-4)
- Marbofloxacin-d8 (CAS 1185053-37-5)
Recommended Standards
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- N'-((1H-Indol-3-yl)methylene)-2-methoxybenzohydrazide (CAS 113143-32-1)
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- N-(2-(1H-Pyrazol-3-yl)-1H-indol-4-yl)acetamide (CAS 827318-19-4)
- Methyl 2-amino-4-(4-chloro-3-methyl-1h-pyrazol-1-yl)butanoate (CAS 1342486-53-6)
- Vasonatrin Peptide (VNP) trifluoroacetate salt (CAS 141676-35-9)
Why CATO?
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